I have a DVR so I never watch anything when it airs-except
Life On Mars, which is fabulous, IMO.
Heroes-I'm there.
Fringe-stupid but amusing.
Sarah Connor-I WANT to love it but am afraid it will go the way of the dodo-I already got burned on Journeyman and Jericho and I don't want it to happen again.
Bones-gotta have my Bones!
Charlie Jade-has Firefly syndrome-good show, short life
Primeval-if you have BBC America, this one is worth checking out. I let it build up a few episodes then marathon it-its more fun that way
Grey's Anatomy and
Desperate Housewives-like a car crash, it horrifies and yet you can't look away.
Cold Case-If you have to watch a police procedural, at least this one has an elf on it!
Did I mention
Life On Mars?
Stargate Atlantis-dumb plots but good character interaction. And every once in a while you get an episode like
Last Man....
As far as comedies-well, when I want to laugh I watch
Sanctuary. What's that? It's supposed to be a drama?

My bad.
And when the brain requires rest-
House.
I forgot 2.
Life, because its quirky, and
Eli Stone, because its quirkier.