I think one issue, at least with some versions of Windows, is that Windows occassionally checks the hard drive and floppy drive when there is no good reason to do so, which not only adds to energy use but also to wear and tear. It might be less of an issue with XP and Vista, but it was really noticeable with 98 and Me. An old 98 desktop with a metal case made a loud banging noise if there was no floopy in the drive whenever Windows checked that drive during Sleep mode. Me simply ran down the batteries of a ThinkPad by restarting the hard disk quite often when in Sleep mode.
Even Vista, I have noticed, sometimes checks the floppy drive when there is no real reason to do so other than to make venders of peripherals happy. I've also noticed that with Vista the hard disk often races for no apparent reason.
I have not seen a computer with a floppy dirve for years.
What kinds of things do you use them for?
I have one in mine. It helps keep dust from entering the case, though not as effectively as the plastic panel. I can't find the plastic panel though...