Take a shot when...
Kira tells someone how things were done in the Resistance.
---Two shots if the person she's talking to clearly doesn't give a damn.
---Three shots if you don't either.
Odo remembers that he can shapeshift in a fight.
---Two shots if the writers have clearly forgotten that Odo can't be harmed by something. (ex- a bat'leth)
Worf is shown working on the station (as opposed to the Defiant).
---Two shots if that work does not involve attending briefings or dealing with Klingons.
---Three shots if that work doesn't invove manning tactical either.
Jadzia acts in a manner that would get most Starfleet officers court-martialed.
---Two shots if Sisko acts approvingly.
---Three shots if Sisko attributes the behavior to Curzon.
O'Brien gets beaten up, tortured, or emotionally traumatized.
---Two shots if O'Brien acts jovially in the very next episode.
---Three shots if O'Brien acts jovially later on in the same episode.
---Four shots if Keiko makes things worse.
---Five shots if Keiko was responsible in the first place.
---Proceed immediately to detox.
Jake fails to appear in an episode.
---Two shots if you didn't realize it until after the episode.
---Three shots if Jake appears and you realize that you had forgotten he existed.
---Four shots if you have no idea who I'm talking about.
Ezri babbles.
---Two shots if Ezri has an entire conversation without babbling.
A Miranda-class ship explodes.
---Two shots if a Miranda-class ship is shown having survived a battle.
---Drink the whole bottle if any Federation or Klingon ship not containing major characters is shown to have shields up.