Yes, but not in the way you mean it.
Setting things in a space station or in the delta quadrant or in a prequel aren't what I'd consider changes to the nature of the shows, and it's the latter type of changes that I find gratuitous and nonsensical:
- DS9 decided to veer away from TNG's unbridled humanism by featuring the whole "prophets vs pah-wraith/Sisko's a messianic figure and eventually accepts it/hackneyed firecaves duel/praying the Dominion reinforcements away..." manichean themes was extremely stupid.
DS9 had great episodes, but those things just reminded me of primary school catholic propaganda classes. TNG had more refined ethics discussions (as did TOS, but with significant executive meddling hampering it), whereas DS9 often reduced it to "ME GOOD, YOU BAD!" - a completely unnecessary and childish tone change.
- VOY went back to TOS/TNG ethos, so I don't know if it counts as change. It's a revert.
Shame the execution was too often lacking, because the show could really shine (and occasionally did).
- DSC turned Trek into a pure action fest. "Star Wars: the live action series" would be a more appropriate name for it, tbh.
Those changes, with DSC's being sold as "modernisations" (are modern audiences brainless? Do they need to be patronised so?), are the unneccessary changes, in my opinion.
Changing the nature of the shows. Changes in setting are irrelevant, as far as I'm concerned; I don't care how the allegory is framed, only about what it's about.