I thought about this while watching Bashir attempt to beat Quark in "Change of Heart." Quark managed to distract Bashir by talking about Dax, but he wouldn't be able to use a similar tactic with Spock (not because Spock doesn't love, but because Quark wouldn't know him well enough to push his buttons). Would Spock be able to beat him? He has shown an ability to master complex games (three-dimensional chess), and could likely learn to play tongo if given the opportunity.
I would love to see the look on Quark's face when he realizes he's been beaten by someone who's half hew-mon.
I would love to see the look on Quark's face when he realizes he's been beaten by someone who's half hew-mon.