Well, if the Creationists feel targeted by the show they're not just being paranoid; the creators clearly consider it their brief to push back against misrepresentations and misunderstanding of science being used to further political/social agendas. That said, there's not much in "A Spacetime Odyssey" that's likely to accomplish that - just many proud assertions of scientific integrity. That's the kind of thing to bring cheers from people who already agree with them rather than enlightenment to the uninformed, misguided or uncertain.
Well it's doubtful anything would have convinced the vast majority of creationists out there-- and that's assuming they even made the effort to watch the show in the first place.
But for all the criticism on here (and I do agree the storytelling isn't quite as focused as it could be), the one thing I think the show IS doing really well, like the original, is just exposing people to a vast array of ideas and scientific concepts they may not have heard before (like being made of "star stuff"), and providing a better perspective on just how inconceivably old and huge our universe is (with things like the Cosmic Calendar), and showing the many amazing and incredible things scientists HAVE discovered about our world and universe so far (such as with the "hidden cosmos" around us from the last episode).
It's easy for us to take all this stuff for granted, but there's a great many people who have likely never heard some of this before or given it much thought. And given the state of science education in this country (and the people who insist on believing ridiculous things), I think it's probably enough just to expose people to the basic ideas and concepts.