I've spent my entire life being one of those people, I'm not going to contribute to their mockery.
I don't know. I'm one of those folks, too, as are most of my friends and colleagues, and I frequently laugh in recognition at the situations and dialogue on BBT. "Been there, had that very same comic-book debate."
Says the guy currently sipping coffee from a Star Trek mug, while sitting in an office adorned with action figures and autographed photos of everyone from Nichelle Nichols to the Creature from the Black Lagoon . . .
I have known multiple people very similar to each of the characters on the show, not to mention seeing a little of myself in all of them. That's why it works.
The same can be said for other sitcoms like Modern Family, The Middle, Everybody Loves Raymond, All in the Family, and on and on. These shows work because there's more than a little reality behind them.
Seems to me that a lot of nerds who don't like Big Bang have the same complaints. It hits a little too close to home for them, and that makes them uncomfortable.