...if the show has to be 25% different, I wonder what a Galaxy Class starship would look like in the new universe. It seems to me that Trek likes kewlness over realness. Part of what made the Refit and the Galaxy great, I think, is that they didn't go just for kewl. So many later ships it's harder for me to buy as real. I wonder how they'll reinterpret the Enterprise-D, as I'm sure it, or something similar, will appear in some fashion on the show, at some point.
Arpy, the Enterprise-D is thirty years old. We feel her day is over.

Seriously, though, I doubt we will see anything like the D in the new Picard series. At least not associated with Picard. There might still be Galaxy-class ships in service, but we might not see them. Especially if the 'families aboard ship' thing was abandoned as a bad idea. And it was a bad idea, because who wants babies and small children subjected to the frontier of absolute unknowns?