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It's hard to imagine anyone other than John Candy as Uncle Buck...unless they really get lucky in casting.
IIRC, there was an Uncle Buck TV series back in the early 90s, not too long after the movie had came out. (Though, I think, before Candy's death.)
Looking it up on Wikipedia and... Yeah, it lasted for one season -22 episodes- and was... YEEESSH. Centered around Buck getting the children following their parents
dying in a car accident!!
Buck was played by comedian Kevin Meaney.
I remember this show existing but I don't remember ever watching it.
The horror.
The horror!