Edit: Sorry about the length, dudes. It got away from me.
Lacking such a geographic concentration, no, it's not something worth fighting for. Worth funding relocation for, perhaps, like minorities on the wrong side of the border, but not enough to abrogate the liberty of the state's majority.
I understand you probably mean a
voluntary relocation program, but why should a United States citizen who lives in the United States ever need to move to remain in the United States?
Liberal democracy has never been solely about majority rule. It's also been, perhaps even moreso, about defending individuals from being deprived of their rights.
In the hypothetical scenario where a majority of Alaskans - say, 80%, given your numbers - support independence, granting that independence is a natural conclusion of democracy. It does not follow that the 20% who dissent are having their rights revoked as citizens, any more than a minority of those who desire independence in a liberal democracy (like the real Alaskan independence party) are having
their rights revoked.
I guess the core of the disagreement is that I'm not sure a right to self-determination exists per se. A right to armed resistance against an oppressive regime certainly does and while the outcome is often the same, the requirements for justification are certainly different.
It strikes me that any country which
would permit, of its own volition, a referendum that would carve away its territory and tax base, cannot be a country unfree enough to justifiably oppose. (Not that a country unfree enough to resist secession with military force would necessarily be worth opposing, itself.) By what metric can a Quebecois express that he or she is oppressed by Anglophone Canada?
They would just be expressing a minority opinion in a democratic state, something that's always been a reality of democratic politics.
There's a bit more to it than that. They would be forced into a rather unpleasant situation, at least: choosing to be resident aliens in the place they've lived in much or all of their lives, or or choosing to leave their homes and repatriate themselves to the newly-diminished U.S.A.
(Although I suppose it's possible that a dual citizenship regime could be instituted, which would alleviate some of the unfairness.)
And it is not a categorical evil for a democratic mandate to desire seperation from another democratic country.
I'll back off from the term
categorical evil. (But I don't want you to feel like I'm shifting the goalposts--so I'll just admit I'm not prepared to argue strenuously for it, and may be wrong about it being wrong in all circumstances.)
Instead, I'll focus on the evil of a state seceding from a liberal democratic regime such as the United States.
If Alaska were to, this moment, draft a law that restricted a woman's constitutional right to abort, and attempted to enforce it, the federal government would prevent them from doing so--up to and including using force if the confrontation escalated to an insane degree.
Instead, however, Alaska
secedes first. People have been convinced that self-determination is a right, and that secession should not be opposed. Alaska then immediately outlaws all abortions in cases where the life of the mother is not threatened. They are certainly within their right to do so as a sovereign nation.
I'm by no means saying this is what would happen (particularly in Alaska, which as I understand it is rather libertarian on the specific issue). I'm saying only that when you have a government which defends individual rights to the extent that the United States does (and by no means are we perfect, but we are pretty good at it! as is the UK, as is Ireland, as are most of the EU countries, even I'm-really-mad-at-them-right-now France), it seems unlikely that any state government that is opposed to it would be willing to provide greater protections, and would be far
more likely to provide fewer.
And should the U.S. be willing to abandon its citizens to an unknown like a rogue state government, why should anyone be willing to pay their taxes or obey the United States' laws? They would lose their legitimacy, in my eyes, if I knew that as soon as a majority in my own state formed against the Union, I too would either be required to run for the dubious safety of new interstate border, or be abandoned to be thrown into the prison for Democrats the SC GOP built in Fort Sumter.
Confederacy's a whole 'nother kettle of fish, obviously. When your democratic mandate is about you protecting your right to deny the democratic mandate to many of your country's labourers, it's kind of a circular logic... but it doesn't mean that any and all secessionism is categorically evil - West Virginia's own secession from Virgina over Virgina's secession from the United States is perhaps too convenient an example here.
WV's secession is a special case, anyway. Seceding from seceders to stay with the sovereign? That's just weird--and in any event, creating a new political subdivision isn't the same as creating a new sovereign nation. (Federalism issues about the extremely qualified sovereignty of U.S. states aside.)
And as I said before, there's a right to armed resistance and a right to secede from a
tyrannical government (Nazi Germany, the Soviet Union, the British Empire). But it's at best selfish and insular, and at worst--as you note in the case of the CSA--a bid to be able to exploit one's own population without the sovereign's interference.
Not that I expect Scotland would reintroduce slavery.
Heck, I was never totally on board with
our secession from the United Kingdom... it
was justified, although it's really questionable whether we set up a
more moral government or not. Granted, this is from a 21st century perspective, where every 18th century regime, even the contemporaneously "good" ones, looks like a steaming pile of shit.
GodBen said:
I'm hoping that this is some sort of parody that I'm just not getting.

Otherwise it is right up where with "You're either with us or against us" on the scale of blinkered nonsense.
No, although I
was kidding about using nuclear weapons on Alaska.
I would be prone to looking on anyone who attempted secession from the U.S. as an actual or potential enemy, and certainly a jerk. To paraphrase Voltaire, I may die to defend someone's right to
demand secession all he wanted, but that doesn't mean I'd be cool with letting them go and
do it.