Here's a quibble I have with STIII - when Saavik lambasts David for his use of protomatter.
SAAVIK: It's time for total truth between us. This planet is not what you intended, or hoped for, is it?
DAVID: Not exactly.
SAAVIK: Why?
DAVID: I used protomatter in the Genesis matrix.
SAAVIK: Protomatter. An unstable substance which every ethical scientist in the galaxy has denounced as dangerously unpredictable.
DAVID: But it was the only way to solve certain problems.
SAAVIK: So, like your father, you changed the rules.
DAVID: If I hadn't, it might have been years, ...or never!
SAAVIK: How many have paid the price for your impatience? How many have died? How much damage have you done? ...And what is yet to come?
She's implying that David was responsible for all the death and destruction in STII and STIII. And, she manages to get a dig in against ol' Jim Kirk for good measure!
However, there's no reason why protomatter (causing Genesis' unstable nature) would have affected any of the conflict preceding the Genesis meltdown. The first stage of the experiment - the Genesis cave - seemed to be chugging along okay, and, in any case, the Genesis torpedo lifted by sticky-fingers Khan was still just an experimental prototype and not necessarily the final delivery device.
As an analogy, consider a researcher in a laboratory, struggling to find a cure for a deadly virus. In his research, he may have to use dangerous and deadly materials, including deadly strains of the virus itself. Khan comes along, as he does, and steals the deadly virus and uses it to wipe out a planet.
How many have died, David, due to your reckless disease research!?
...That's how I see it, anyway. A misplaced guilt-trip if ever there was one.
Heh, after visiting the Memory Alpha page on protomatter:
In 2374, the USS Voyager encountered a nebula that contained high concentrations of protomatter. Neelix, who had worked with protomatter in the past, was killed while protomatter was transported into a canister he was holding. Seven of Nine subsequently brought him back to life with her Borg nanoprobes. (VOY: "Mortal Coil"
Annnnd this is why I don't watch Voyager.
