Now that Barry and Hal are back Gwen along with Uncle Ben are two of the longest dead characters out there.
No doubt Marvel will find a way at some point to reverse that. Especially since Gwen is going to be such a big role in the new films. Gwen never made it her college years so its new ground for her in the movies.
Gwen, to me, is a strange anomalous character. I have read some of the Essential Spider-Man series which has Gwen in it and she seems to be the "caring" girl-next-door type as opposed to "party-girl" MJ Watson in the early years. After that, I've only heard mention of her in the comparatively current comics - Spider-Man: Blue, Sins Past and various other references that Spidey/Peter make from time to time.
Based on what little I know of her, I don't have a hard time thinking that she got involved with Norman Osborn - it's the standard cautionary Red Robin Hood and the big bad wolf tale. What I find very incredible is that she was gone for that long a time to have given birth to the twins (in Europe or wherever) and that Green Goblin had so much technology at that point in time as to do weird genetic experiments on the kids and so on. I know time is weird in the Marvel U - How can you have the same folks age only a decade or so while time moved from the 60s to 2010s! - But I just can't get past the fact that she must've been away for at least 8-10 months (give birth, recover her shapely shape and then "come back" and be thrown off the bridge). Is that supposed to have happened?
Btw, one of the things that I heard mention from JMS was that earlier there was a possibility that the kids would be Peter's (before they became Norman's). How would you have felt if the twins had been Peter's kids?