There will be significant strides in genetic technologies, with a significant population of genetically engineered humans, who will for the most part be little better at the average task than a regular human, and will continue to have to compete with the broader base of regular humans who have above-average talents in given fields; I'm however that they will be healthier, and I suspect that they will be happier;
In a similar vein, there will probably be tailored drugs for those that can afford them, taking the edge off widespread human neurological failings such as depression, etc.;
Somatic gene therapy may exist, but I doubt it; serious, which is to say particularly useful, genetic engineering will be germ-line only, I believe--although I hope I'm wrong;
There will be no strong nanotechnology in the Drexlerian sense, but great advances in materials science based on an understanding of nanoscale physics and chemistry, and I would suspect nanotechnology-lite in the form of biological synthesis of ordinary macromaterials will be possible, although it sort of already is, given that every visible lifeform on Earth is essentially a nanotech-cum-macromechanical device already;
Strong AI will have been developed, although it will likely be the subject of mistrust and fear, and its integration into mainstream society will be slow; weak AI by contrast will likely ensure a freedom from work, although perhaps only in the First World, with the possibility that Third World societies will collapse as the markets for their industrial product do;
There will be no space colonies, probably, and no interplanetary settlements, let alone interstellar missions, but that's largely because we're complete losers.