So, some Sikh guy shows up in Tehran with seventy of his closest friends, and deposes Ahmadinejad? Unlikely. Even the most thuggish (there's a pun in there somewhere) coups, like Saddam Hussein's muscling out of al-Bakr and other rivals within the Ba'ath Party, nonetheless had support within an organized, nationalist party that had significant popular appeal.
The Palestinian Liberation Front in 1970-71 was better organized than seventy guys with attitude problems and above-average IQs, had far broader appeal and popular support, and they couldn't even topple Jordan. How in the world is some lab-made freak going to take over India? Or Pakistan? Or any place worth anything?
Beyond plausibility issues, I don't think the Thousand Augment scenario is all that interesting. It's just the backdrop for some villainy. The Hundred Million Augment scenario has room for moral ambiguity, and better science fiction. With genetic engineering coming along at the pace it is, I wouldn't be surprised that within twenty years "Space Seed" looks about as progressive as "The Jazz Singer."
Even without the prospect of real "supermen" coming to walk among us, the 100M Augment scenario serves as an allegory for the cultural conflict the world is facing right now, between increasingly cosmopolitan global elite and the conservative provincialists who fear the more united, but perhaps a more decadent, more meaningless, and more immoral future that they represent.
Also, fwiw--India has a Sikh prime minister right now, Manmohan (wait for it

) Singh. OMG the war has begun!

But, no, he's not genetically engineered.