From Watch with Kristen interview:
We keep a list of unanswered questions, and we will be trying to answer most of those. Obviously, mystery is a part of life, and mystery is a part of the show. I guess we'll all have to see at the end of the day how satisfied people are, but it is our intention to
try to wrap things up. I don't know if the show will become simpler, but hopefully in the wrapping up of these questions, it will be satisfying.
DL: There are some questions that are very engaging and interesting, and then there are other questions that we have no interest whatsoever in answering. We call it the
midi-chlorian debate, because at a certain point explaining something mystical demystifies it. To try and have a character come and say "Here is what the numbers mean," actually makes every usage of the numbers up to that point less interesting.
You can actually watch
Star Wars now and when Obi-Wan talks about the Force to Luke the first time we hear him, it loses its luster because subsequently the Force has been explained as, sort of, little biological agents that are in your blood stream. So you go, "Oh, I liked Obi-Wan's version a lot better," which in the case of our show is "The numbers are bad luck, they keep popping up in Hurley's life, they appear on the island."
and....
Obviously the big question after last night's episode, leading into that finale, is "How are they going to move the island?" which is a fantastic twist and also, "Is Claire dead?" Is that a question that you are wanting the fans to be asking at this point?
CC: I think that we want the fans to ask, "What's happened to Claire?" I don't think it's "Is she dead?" I think it's like "Where is she?" and "What's going on with her?"
DL: What's fascinating with
Lost is there's a scene where Claire is in the cabin, and she is sitting next to a guy who
is dead, and nobody is saying "What's up with that?" They're all saying "Is
she dead?" I think the more operative question is,
"What is dead?" That's a good question to ask, and one you will certainly be asking over the long hiatus.