Good question, maybe one that goes beyond what's posed and right to the heart of Trek lore.
Does the Prime Directive permit non-interference to the level of condoning slavery, forced family separation, comfort women, puppet governments and disastrous strip-mining? I can see where the Prime Directive concept may have come from in the 1960s and the 1980s, but in the lens of the 2020s, would the UFP actually let the Cardassians get away with that? As Keeve Falor said in TNG's
Ensign Ro in 1991, "you sat and watched behind a line on a map." (I'm taking some off-the-cuff liberties with the exact quote, but you get the intention.)
I can't imagine the Cardassians would have even been able to build DS9 or any of the other "___ Nor" stations--they'd have been blockaded, sanctioned, and totally shut out of any levers of influence. They may have occupied Bajor to solve their shortages, but other major powers would have moved to shut them down harder than if they hadn't invaded.
In short, I think a central premise of the show would have been untenable if it was made today, because the Cardassians would never have gotten that far in the first place. Our collective consciousness now seems less likely to accept the "not my problem" factor posed by the Prime Directive when facing obvious cruelty and despotic behaviour. Cardassians invading Bajor would have just made their problems worse, and they wouldn't even be a factor in galactic affairs.
Basically: we'd be so disgusted, we'd whoop their bony asses without firing a shot. There would be no DS9.
Now, the Ferengi using Bajor and the wormhole as an intergalactic tax haven while igniting a trade war with the Dominion, where the UFP tries to keep both sides happy?
That I could see being made in 2024.
Notwithstanding the rant above, I agree with several others that one of Trek's beauties is it's timelessness. Take out that modern perspective, and DS9 has a storyline for everyone. No matter when we watch it! Bad is bad, good is good, black and white is grey, money drives everything except altruism--which requires money, sometimes the bad guys are good guys, religion is in the eye of both the believer and the atheist, and complexity is...everywhere.

It's really a great show.