Put me down as decidedly uninterested in any more X-Files anything. Dropped off watching the show about two or three seasons before cancellation, checked back in for the finale and was deeply grateful I hadn't wasted two years slogging though whatever they were about only to end it like
that. Never really engaged with any of the spin-offs (Millennium just seemed so dry and dismal, and the Lone Gunman was just cheap and uninspired.) Barely remember that second movie, never bothered with the reboot, and while I briefly considered a rewatch a year or so back, I never worked up the motivation to even take a crack at a "top 10 episodes" only rewatch. X-Files was a product of it's time, and one that really hasn't aged well.
At this point there have been so many X-Filesish shows, that it would be hard to find an approach that another show hasn't alread taken. Which I guess could be a good reason to not even bother, since pretty much anything they do at this point is going to be been there, done that.
Basically. A sci-fi lite/paranormal monster show in the mold of a police procedural is such a dead, stale concept, and it's been both of those things since before the show had even finished it's original run. There's nothing novel about the hook anymore. You can't even subvert and deconstruct it by telling the story from the monster's perspective or something since even
that's been done already.
As a general rule of thumb; remakes, reboots, reimaginings etc. only work if 1) the original premise has some intrinsic merit, and 2) never reached it's full potential on the first go-round. Plus of course the all important and ever elusive: 3) Have something new to add into the mix that makes the retelling worthwhile.
It's why remakes of actually good movies never work. I mean 'Point Break'? 'Poltergeist'? 'Psycho'? Why set yourself up for failure with uphill struggles like that?
In the case of X-Files, not only was the potential of the original concept fulfilled, it was overfulfilled. Wrung dry. Stretched out. Beaten to death and repeatedly resuscitated until it was a shambling, aimless, dead-eyed and zombified shadow of it's former self.
The best anyone could ever hope to do is tell a slightly more streamlined, less rammable version of the show . . . except multiple other shows have already done that in the decades since, so there's really nothing of value there save pure brand recognition.