I guess I'm the lone dissenter, but I'm unimpressed. To be fair, I only watched the first three episodes, but I saw nothing in there to draw me back.
I was expecting McFarlane to apply his Family Guy skills to Star Trek, and I was ready to settle in and laugh uproariously. The jokes immediately struck me as not up to his ability; I'm not averse to the dick jokes, but he's shown he can do really intelligent humor as well, and I find it lacking here.
Worse, for me, are the tonal shifts. Going from humor, on whatever level, to attempted drama, on whatever level, just doesn't work very often, and in this I don't think it worked at all. I had the same reaction to the Buffy series. One moment she's trying to be cool and tossing off one-liners, and the next I'm supposed to feel sad for her because her mother's dead. I could never connect those two Buffies in any meaningful way.