Most of the comedy is tumble weeds passing by because it's not funny. So far the drama is seriously lacking. He's just not doing it right.
I really wish people wouldn't keep making grand declarations about something as subjective as humor. 90% of the jokes work for me. They don't for you. Some people find things hilarious that I just barely chuckle at, other people are completely left cold by things that make me spit out my proverbial drink.
It's one thing if there's an overwhelming consensus that the humor doesn't work, or if you're a long-time fan of the writer's previous humor and this time it's leaving you cold.
But that's not the case. Lots of people find the show's humor funny, even if there's some who are categorically against even oblique references to bodily functions (episode contains one cringe comedy bit where a person discusses colon diseases, yet some people act as if they're watching Freddy Got Fingered).
If he wants comedy and drama mixed together done right, see "Scrubs". If he wants comedy in the work place with quirk, see "Newsradio".
Funny example there with Scrubs. While I enjoyed the show, I almost never laughed at it. The humor of that show was this frenetic machine gunning of quips and people behaving farcically, which I find amusing but not hilarious. Yet I wouldn't dream of declaring Scrubs an unfunny show because it doesn't make ME laugh.
As an example of my sense of humor, here's a random list of TV and movies that have made me fall over laughing - Fawlty Towers, Blackadder 2-4, A Fish Called Wanda, Frasier, Better Off Ted, Parks and Rec, Community, most Apatow comedies. With regards to MacFarlane, Family Guy makes me laugh more often than not.
A more constructive discussion about The Orville would be whether the show succeeds in the balancing act between drama and comedy. If you personally don't find the drama engaging or the humor funny, then that's wholly subjective. But I think the flow of the show is less so, and personally I found the pilot was a bit awkward whereas Command Performance was really great and felt exactly like a mid-run Berman era Quark or Q-focused episode. Exciting but not too serious, the jokes work as an organic part of the story. The pilot was more like "Exposition. Cut to joke. Now some drama. Everyone stop for a joke."