No these things matter of course, in part because the scripts have to be based there and in part because of audience expectations..I'm not saying they will base it on what fans want, but only that fan interest will change based on it's milieu. Eventually the as the season(s) continue the story-line will make or break it, but the setting isn't inconsequential.The universe doesn't matter. The guest actors don't matter. Even the ship design doesn't matter.
What matters is good scripts (and good directing).
And anyone who actually knows anything about Fuller knows not to expect a continuation of the tail-end of the Berman years.