Saying that Sisko blames Picard for Wolf 359 goes too far. Instead, Picard embodies the unresolved issues that Sisko has,the psychological pain he has lived with without trying to resolve. In the context of storytelling, the meeting between Sisko and Picard reveals Sisko's state of mind by comparing him with someone known for his discipline, who himself struggled against the feeling of guilt for the deaths caused by his hand when under someone else's control. That meeting was an extension of the type of struggles Picard endured in "Family."
It's not going to far. initially, before his stint with the prophets, he most certainly blamed Picard for the loss of his wife. The Borg gained all Picard's knowledge during BoBW. This was considered by most and even Picard himself as directly giving the Borg the advantage at Wolf 359; so much so Picard was considered an "unstable element" and prevented from fighting at Wolf 359. He had to disobey orders to join the fight. I agree that issues like this are something Picard has to deal with and is continuing the issues shown to us in 'Family'.
I'm not saying Sisko should have been fired or demoted or hoose-galled or something like that, but I do believe Sisko should have made some sort of amends for his actions the first time he meets with Picard.
Something like this:
As written:
"SISKO: Captain, regarding our conversation about someone to replace me.
PICARD: Yes, I'm sorry I haven't had time yet to communicate that to Command.
SISKO: I would prefer you ignore it, sir.
PICARD: I'm not sure that I can. Are you certain that's what you want, because we cannot afford to have an officer who's
SISKO: I'm certain, sir.
(They shake hands.)
PICARD: Good luck, Mister Sisko."
Simply add:
SISKO: Thank you sir.... and Captain, I was out of line with my comments concerning Wolf 35.....
PICARD (interrupts): Commander, I understand... it's a burden I bare every day. (Picard would say something better than that I'm sure, but you get the drift)
)
