Apart from 75% of people watching going "Who the fuck is Susan..."
"Which Time Lady?!"
"The one you abandoned... Grandfather."
I could understand a future incarnation of Susan turning out to be mentally disturbed. She would have been a Gallifreyan among humans, remaining young while her husband and everyone else she knew grew old and died, and her beloved grandfather never kept his promise to return.
People were talking about the possibility of a female Doctor as long ago as the Peter Davison/Colin Baker regeneration.
Romana wasn't abandoned. She chose to stay in E-Space of her own free will, because otherwise she would have had to return to Gallifrey - and she definitely didn't want to. Staying in E-Space with Biroc and the Tharils was her only way of avoiding that.
For those of us who remember Roger Delgado and Anthony Ainley, the modern incarnations of the Master are so far from the suave, debonair villain of the '70s and '80s, that they are practically different people. Delgado and Ainley's portrayals were of a villain who could be utterly charming while being utterly ruthless, but ever since the TV movie, the Master has just been portrayed as a creepy, disgusting caricature.
When Missy said "You left me behind" I said "fuck me: IT'S-ROMANA!"
That stuck with me so hard that when Missy admitted who she really was I still thought, "Why is Romana ####ing with him?"
He didn't leave her behind. She
chose to stay.
It be really warped if the Master and Romana were the same time lord. But Romana (aka Fred) was never the warped.
From the Doctor's reaction to "Romanadvoratrelundar," I'm guessing most Time Lord/Lady names aren't so convoluted.