Unless the human brain changes a lot in the next 300-odd years, I think there will still be a need for something weekend-like. I'm fortunate enough to have a job I love, and going in on a weekend is never something I object to, but I still find that if I focus on it for the majority of the day too many days running, I'm not as "on" as I normally would be.
On the other hand, maybe 24th-century conveniences like replicators -- not to mention not needing to worry about things like money -- reduce the stress level in people's personal lives so much that their leisure time is much higher-quality than ours is today, and thus more relaxing. If none of your off-hours go into paying bills, shopping for groceries, doing laundry, fixing things around the house, etc., that might make recharing your batteries a lot easier.