Can, sure. It's just the "probably" that I think is an overstatement.
As I said above,
Flash Gordon got a boost in public awareness from the '80 movie, which was more successful and influential than the '79
Buck series. So FG has had several screen adaptations since while BR has had nothing outside of print and RPGs. So while they were of near-equal prominence in the past, these days I think FG has a much higher profile.
And I feel the 2007 FG series started getting good about 1/3 of the way through, not just toward its end. The problem was that the first 1/3 was so dire that people gave up quickly.
Whyever not? The core idea is about a present-day person changing the future; that doesn't require the character to have any specific identity other than contemporary. And who cares if a few fragile-egoed misogynists make noise about it? Their kind has spent millennia ignoring the views and opinions of the majority of the human race, so it's not like we owe them anything different. Heck, offending people like them is proof you're doing something right.
Indeed, gender-swapping Buck Rogers might add something interesting to it. In a way, Buck Rogers is a portal fantasy, a story about a protagonist from the everyday world swept unwillingly into an alien realm. In the fantasy genre, portal stories often have female protagonists, going back to Alice in Wonderland and Lucy in Narnia. Alternatively, portal fantasies
often appeal to LGBTQ readers because of the themes of alienation, escape, and finding a place where one belongs. So there's certainly potential in the idea of reframing Buck Rogers in the vein of a modern portal narrative, which could revitalize it in ways that just trying to duplicate past nostalgia couldn't. The original BR was basically a riff on the same standard white-savior narrative as Tarzan, John Carter, and Flash Gordon, a man from contemporary Western culture proving himself inherently superior to the inhabitants of an exotic culture. To give it relevance to modern audiences, it would need to embody a less outdated and discredited trope. Maybe Buck thrives in the future, not because of inherent superiority, but because it allows him/her/them to embrace their true self in a way they weren't allowed to do in the present.
(And before anyone objects that "Buck" is an inherently masculine nickname, I had a high school classmate named Rebecca who was nicknamed Buck. And of course there was Kara "Starbuck" Thrace.)
Yes, that's the source of the "Gene Hunt effect" that
diankra mentioned earlier.