How about Edith Keeler?
Admittedly, that character didn't have the issue of having to work in a long term romance arc.
Since Kirk was her employee at the soup kitchen, it was unprofessional and innappropriate for her to engage in a romantic relationship with him.
Snap!
+1

whoa!
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bringing back the main topic, some fans in other sites seem to be resigned about the fact that Pegg will do nothing with it [the romance] in trek3 because it's not 'his thing', or that the movie will mostly pander to tos fans only (??) and thus push Uhura back to the background - or marginalize Sulu and Uhura (there is this, a bit stretchy IMO, theory that the omaze videos show the way the characters are 'grouped' in the whole movie and thus you won't see the dynamics from the first movies like S/U, or Kirk/Bones or Kirk/Uhura and Kirk/Uhura/Spock. Quinto also seemed to imply that the movie is less the Kirk/Spock show)
That concern seems to be exacerbated by the latest news about filming because according to some sites it seems that only the guys will take part of the filming next week in Dubai, where they are supposed to film a big part of the movie (rumors say so, it's very possible they just film some scenes there and then move to another place for the rest)
To be fair though, and it's mentioned in the comments section of
this article too, Zoe Saldana made a post over her facebook page that doesn't indicate she is done with her scenes in trek,
at all
Some people seem to make a bit of confusion because I honestly think that scenes are never filmed in chronological order
anyway SO even if Zoe doesn't take part of the filming in Dubai, sure I'd find it weird if they really will film a big part of the movie there ( regardless the television series, like one of the comments mentioned, often doing that kind of thing with the characters. It doesn't matter, the movies are a different thing), but it wouldn't mean that we suddenly don't see Uhura in the end of the movie.
Honestly, I have no idea about what the writers will do in the next movie. I mean, if I were to write the story I'd have plenty of ideas because I think you can do a lot of things with the characters still. I think the first movie had an enormous potential and they can tell many new stories without having to necessarily get 'ideas' from the previous movies or the episodes.
Also, with this romance specifically, I honestly think the writers hadn't had enough 'fun' - so to speak - with the fact that he's half alien (beside the fact that he has a hard time expressing his feelings. But that's nothing new) The fact that Quinto often said he'd like to see them explore the pon farr plot I think is more about him wanting to explore Spock's alieness and bits from vulcan culture, than anything else.
Even just simple things like making him speak in vulcan for a chance.. either way, I'd find it hard to believe someone doesn't know what to do with it. In that case, then perhaps they aren't able to make the existing friendships interesting either since they are even more taken for granted and can be as predictable once you have established them IMO.
I never made it a mystery here that the idea of Pegg writing the script didn't really fill me with hope and excitement for this movie, even less when it comes to the female characters. I hope I'm wrong. I won't repeat myself because last time I did I seemed to 'offend' some Pegg supporters here, or came across as a hater which I'm not.
I could be perfectly all wrong about him and maybe he'll surprise me, but, so far, the things he had said and his previous scripts don't make
me hopeful about certain aspects.
I think, for me, my best hope is that regardless what the new creative team thinks about the previous movies, they were able to put aside, perhaps, their own biases and do what's the best for the story and respect the integrity of these characters the way they had been developed so far.
I really hope that the writers didn't think that the best idea to celebrate the 50th anniversary is giving to fans a caricature of the original characters. I'd like for them to celebrate the spirit of the series but this doesn't necessarily mean 'let's turn this into tos'.
I also hope that Urban's McCoy isn't relegated, once again, to making an impersonation of the original character. I'd like to see him do something I couldn't imagine the old character doing and yet it makes perfect sense for this version of him.
I'd, perhaps, prefer it if ZQ had said he interacted with Sulu - example - the most (
"Have you disengaged the external inertial dampener?" 
) because it would be a new thing .. while the Spock/McCoy dynamic is one of my favorite things from tos, I don't feel the need to see it getting duplicated at any cost in the reboot too.
I don't think the characters necessarily have to be stuck in old dynamics only, and more than anything I'd like it if the writers let this reboot be its own thing for good.
Old fans will like or dislike it regardless if it's a carbon copy of tos, if everyone had wanted the reboot to be totally like tos I don't think the first movie would have been so successful and embraced by critics and fans.