Okay, I was think today about what I would do if I were writing the third movie, I've only got it partly worked out so bear with me or feel free to ad on.
It's another two years down the road, the presumptive time when the sequel will come out (the movie made $118m opening weekend domestically compared to it's $86m production budget) and this time Alan is the one getting married.
Not being one who's exactly "on the market" Alan is getting married to a Russian mail-order bride but through his well-to-do parents Alan is throwing a huge, lavish, wedding. Dying for a taste of revenge Stu decides to thrown Alan's bachelor party; Doug and Phil try and to stop him but eventually they go along with it.
Stu's plan is to invite Alan over to the dentist office for a toast before they go out and have fun. Alan's drink will be spiked with a drug Stu has on hand in the office, they plan to put Alan through hell while he's out of it, but unknown to Stu there's a leaky NOS valve in his office which combines with the alcohol he and the other guys are drinking, as well as the drugs spiked in Alan's, to send them off in their night of antics.
They toast, camera pans to the time-lapse of the night passing, bright flash to the following morning with the trio waking up in a drunk tank in TJ, their wallets, passports and phones are all gone all they have on them when they get out of the tank is some change, a bus stub, and a key to a storage locker back in the LA bus terminal.
I've not quite settled on who the missing person would be but, fuck it, we'll make it Doug again.
How about when they wake up, they are standing over the bloody corpse of Stu... and Alan is holding the knife...
Hilarity ensues.