Paris: Do you think I can start his Enterprise books without having read previous books without spoiling too much? I haven't read much Enterprise yet including the Romulan War books.
Well, Rise of the Federation is meant to be the start of a new story and thus a good jumping-on point, but there are some spoilers for what came before.
And it works that way very well, imo. I picked it up primarily because I am a fan of Christopher's Trek novels and hadn't read a single Enterprise novel (and haven't even watched all the episodes of the series) and I never once felt like I was missing anything.