I don't know how much or how little bearing this will have on the Picard Series but what does everyone think the status of the Alpha Quadrant powers will be in 2399? I think the Breen are still part of the Dominion. How relevant that is the Picard Series, probably not very. The Klingons are probably still allies to the Federation. Maybe not as close as when Martok was in power but still on good terms. If only because they want this series to be different from Discovery. The Romulans are a mess after the destruction of Romulus. Cardassia is still a long way from being what it used to be and will never become that again. They're in the background as the type of third-rate power Dukat never wanted to see them turn into. I think the Ferengi can go one of two ways: 1. I heard somewhere that Rom was equated to the Jimmy Carter of the Ferengi (I don't remember the source off-hand). If this "Jimmy Carter" is succeeded by a "Ronald Reagan", then it's possible that the Ferengi have gone back to their Old Ways and are worse than ever. 2. Under Rom they become closely allied to the Federation to the point where maybe they might even join the Federation. If they join then that potentially leads to 2A... 2A. I strongly doubt this will happen, I'm pretty sure it won't, but depending on how "Real World" the Picard Series wants to get or how much they want to delve into Current Events.... they could have a Ferengi as President of the Federation, who Picard is against. Picard is the Bernie Sanders to this Federation President's Donald Trump. But they probably won't do that.