Just brainstorming here, I vaguely had in mind a primarily planetary adventure, like “The Slaver Weapon” or “The Cage” or “Friday’s Child” or Forbidden Planet. I read a novel called The Galactic Whirlpool which involved the crew boarding a generation ship - that would be a pretty cool scenario (check out Metamorphosis Alpha?). I think the best Star Trek episodes involved landing into a new situation where they meet the natives, who are not a known entity — i.e., primitives or ancients, not Romulans or Klingons, though they can be involved as a third party (but prefer Gorns and/or Orions for this, I think). Another good setup is when the Enterprise has been taken over and you have to fight to take it back (“Space Seed,” “By Any Other Name,” “Day of the Dove,” First Contact perhaps most D&Dishly).
A few years ago I ran a Star Wars one-shot which was an escape from a Star Destroyer scenario. A straight-forward premise harkening back to the original movie which just nailed the feel of SW. I’m trying to think what a ST equivalent would be. Basically The Cage, right, just with a little more meat?