TerraNovan
Lieutenant Commander
Yeah and you didn't answer some very basic premises, which are gonna arise the second you mention transhumanism.Another thought, in terms of story, the UFP will not only be wrestling with issues of trans and non-trans humans, and outside aliens, but simply the fact that they won't know how they'll end up...whether what is happening will end up for the betterment of civilization or not, much like the debate is today. It makes the issue more complex...though of course everyone feels what they are doing is right.
RAMA
Trans humans or the singularity, is near impossible for star trek, unless you do a total reboot, and alter the show to the point that it is no longer star trek. Ignoring the technical challenges of the singularity on television. The writing for it is near impossible, because it creates plot holes that aren't easily resolved.
If the doctor can copy his unimatrix, and have multiple copies of himself, why isn't voyageur using this to aid them since they are desperate to get home. Sure you can make up some reasoning, but a patch work of made up reasonings does not add up to a coherent show.
I explained how they could do it and they dont have to do any tinkering with the past at all.
What happens when the romulans, get a hold of this tech, and can multiple their armies at a near exponential rate. Your gonna be facing an army of infinity, you can say this would make a good show the reality is it would make a show unbelievable.