They've almost all been very successful and very busy. Many returned to the theatre, which you won't see on IMDB filmographies. Most do regular guest roles and recurring roles on TV shows, and supporting roles in movies.
-Jonathan Frakes is a successful director in the TV circuit.
-Levar Burton recently Co-produced the "Roots" reboot, and I heard he's working on a new reading rainbow show.
-Sirtis has done a lot of films
-Stewart became an A-list actor
-Spiner is still acting in both film and TV guest roles, and currently has a recurring role on a show.
Most of the Ds9 crew have followed a similar path. An exception is maybe Avery Brooks. Im not sure what he has done.
A lot of these guys are past retirement age now. Andrew Robinson and René Auberjonois were already nearing that age twenty years ago when Ds9 was still on air.
I'm more familiar with the Voyager cast.
-Mulgrew is one of the starring leads on "Orange is the New Black." She also does a lot of voice acting and theatre performance.
-Bob Picardo and Ethan Phillips do a lot of theatre work(they earned their fame on Broadway originally) they also do a lot of TV guest roles and films.
-Robert Beltran has also returned to the stage, doing plays and musicals in the LA area.
-Roxanne Dawson has become a famous TV director, working on many hit shows.
-Robbie Duncan Mcneill was EP(and directed like half the episodes of "Chuck." One of the greatest shows ever! He's also directed and produced many other shows.
-Jeri Ryan is still a successful actress
Enterprise-
As noted above, The Bakula is still an "A-List" TV actor and has the lead on the latest NCIS iteration, which has been pretty successful. He also has the reputation as the "nicest man in Hollywood."
-Jolene Blalock has done TV and film(and is still gorgeous.)
-Conner Trinneer same(and this is hilarious. He recently played "George W. Bush" in the Tom Cruise movie "American Made."
Likewise the rest of the Enterprise cast.
I heard Hoshi Sato got into political activism and is an outspoken member of "California should secede from the union movement." I'm sorry. I'm sure they have a name.