You can, but suppose, as I said above, there are reasons why a short cut would be preferable/required? Maybe there's some kind of regulations governing the region, acceptable travel throughout, treaty complications, etc, or episode plot reasons.
If you have access to other forms of FTL, you can literally just bypass it by using those.
If you have Voth Style TransWarp, you just outrun it by going faster like "The Flash".
If you have Borg Style TransWarp Conduit, you bore a tunnel through Subspace and punch right through it.
If you have Quantum Slip Stream Drive, you just enter the Quantum Realm and bypass it.
If you have CoAxial Warp Drive, you just fold space and jump past it.
If you have SubSpace Vortex Generator, you just enter Subspace and bypass it by entering Subspace.
If you know how to open a Spatial Flexure like Q Junior, you can literally make a tunnel through space to bypass vast distances, the only limit is knowledge on what is on the other end so that you don't open the Spatial Flexure into a Star or Black Hole and get yourself killed. (Good Knowledge of Space Cartography is a must along with aim and calculation capability). Remember, Discovery almost jumped into a Star because they lacked precise control, with the Spore Drive in the early days. Messing with a "Spatial Flexure" using only a Deflector Dish could be risky, but the major risk is your knowledge of what's on the other end and how far did you map space ahead of you so that you aren't waltzing into a Black-Hole / Star / Spatial Anomaly / etc.
If you have a Graviton Catapult, you enter Null Space and bypass it.
If you have a Spore Drive, you enter the Mycelial Network and bypass it.
If you have a Displacement Wave Generator (CareTaker Tool), you can move vessels past it to anywhere in the Galaxy.
If you have a Soliton Wave Driver, you can create the Soliton Wave and ride it at FTL to go through it.
If you have a Temporal Drive, you can literally travel through Space-Time to any where you want at any point in time.