Hmm, not what I expected Madame Web to be. Looks like it's basically an origin story for a team of Spider-heroines, with a considerably younger, costumed version of J. Michael Straczynski's Ezekiel Sims character as the villain.
Looking into it, I see that the three women the main character is protecting are all characters who've been Spider-Woman in the comics -- Julia Carpenter, Anya Corazon, and Mattie Franklin. Interesting approach. Come to think of it, didn't Julia become Madame Web in the later comics? Anyway, Ezekiel's presence implies they're going for something like the "spider-totem" idea of how all spider-powered superbeings are linked by a "web" of destiny or some such thing.