Commander Crusher: well, assuming there are no casting changes (sorry for screaming at the top of my voice there
), THAT would be something to behold. 
[There'd have to be a different story for how Jack died, but I suppose that Picard's "brainy-ness" would befit a CMO.]
On the other hand, what about potential character development problems akin to Janeway's?
Regarding Worf: It would have been interesting to be treated to an XO Worf before the post-NEM TNG relaunch novels. At the very least, he was the one TNG character who fit the least amongst the DS9 crew.


[There'd have to be a different story for how Jack died, but I suppose that Picard's "brainy-ness" would befit a CMO.]
On the other hand, what about potential character development problems akin to Janeway's?
Regarding Worf: It would have been interesting to be treated to an XO Worf before the post-NEM TNG relaunch novels. At the very least, he was the one TNG character who fit the least amongst the DS9 crew.