I like to see the U.S.S Enterprise NCC 1701-C I know we would know the fate of this enterprise but what a re cast just trying to think of a good lead lady to play Rachel garret any suggestions and then there's Kyle. You could really do some good things with new crew.?
The 1701-C would be great setting for a series based on a huge-overarching plot. Hell, you even start the first episode with the Last Stand of the Enterprise, and spend the rest of the series showing the chain of events that get you there.
It would piss off the Canon Nazis (though I'm betting there's enough space in between the words of dialog in TNG Redemption to squeeze it through), but you can even change up the ending so that some of the crew survives and has something of a happy ending, though it would be overshadowed by the defiant, yet tragic loss of ship and captain.
In order to sell merchandise, and generally provide a sleeker modern design befitting current tastes, you could also remodel the ship. Something along the lines of the original Probert proposal. Again, it would draw the ire of the Nazi's, but that ship is kinda ugly to begin with. It just lacks the refinement of other ships.