It's possible... though what I wouldn't want is rounds and rounds of repetitive/mindless action games.
I liked adventures the likes of 25th anniversary, Judgment Rites and A Final Unity.
What would be interesting though is to for example create a combination of different genres... predominantly focusing on the adventure/rpg aspect, but also combining Bridge Commander style of gameplay for space simulations during combat scenarios, and perhaps a bit of an galactic overlay for fleet deployment if necessary (for specific situations).
Basically combining multiple things into one big game (not an MMO though).