Just look at how Paramount has up ticked Khan tie in merchandise
That sinks it. It's Khan for sure.

Chekov better invest in some good earplugs.
And remember everyone, this won't be
Wrath of Khan. They're starting from the get-go, with the discovery of
Botany Bay. Or maybe even that has changed; Khan and crew might have been discovered earlier by who knows who, and by now have established a base of operations on some far-flung world.
Khan may have had many years to plot his attack on those stuck-up mundanes of Earth who refuse to acknowledge his inherent superiority. Who knows, he might even have allied with the Klingons (who have their own squirrely history with genetic augmentation - wonder how that might play out with them.)
The story could be completely different this time around. Old Spock can certainly warn Starfleet not to trust that Khan guy, when they finally become aware of his existence, but there's no telling whether that warning will be of any use.
I've always found the whole Augments story to be fascinating and underdeveloped. The Federation is so wonderfully open-minded and blase about everything, but they go all paranoid and nutty about this one thing, genetic engineering. That suggests a truly deep-seated trauma, at least for the humans in the Federation, that is an interesting deviation from their overall rationality.
I'd like to see at least a brief backstory sequence delving into the historical "Eugenics War" (aka WWIII, seems pretty likely now that they have to be merged.)
Antonio Banderas, Naveen Andrews, either would be good. Though I think Antonio would be a bit more name-worthy.
In the age of political correctness, they aren't going to dare to give the role to a white guy. Someone of actual real-life Indian descent like Andrews is far more likely. I'd love either him or Sendhil Ramamurthy, who might not be a good enough actor to play a bad-ass, but day-aaam, he certainly looks like a human who's been engineered to be like unto a GOD!
The bad guys racial backgrounds are always incidental to their always human motives.
Khan's motivations were racial. If he had been a mere un-augmented human, he wouldn't have an overweening sense of superiority and would not have attempted to finish the job he started way back when, to dominate the inferior non-augments of Earth.
Star Trek is full of aliens with motives that spring from some inherent quality of the race - Klingons, Vulcans, Ferengi, Cardassian, Dominion, Borg. But the poor Rommies can't play that game because nobody's ever given them the proper definition. That's just not right (and not as much fun).
Those half-white half-black guys could have been pockadotted and the same story could have been told.
The key characteristic of their species was not how the makeup was applied, but that they defined their racial differences according to something that, to humans, was so trivial that it wasn't even immediately apparent (and therefore implied that human perceptions of race were equally absurd). They would have had the same definition if they were polka-dotted (maybe the size of the dots was the difference?) and would have been racially motivated just the same.