I'm wondering if it'll have the same continuity/cast as JL: Crisis on Two Earths. I kinda hope it doesn't, though, since the JL voice cast in that one was kind of unimpressive.
Unlikely, since nearly all of these DC animated films have been separate from one another, continuity-wise, and the previous JL animated films had different voice casts.
But they've already made one exception to that pattern --
Superman/Batman: Apocalypse was a sequel to
Superman/Batman: Public Enemies, with the same cast and continuity. And the producers considered sequels to
Wonder Woman and
Green Lantern: First Flight, but those projects were shelved due to disappointing sales of the originals. So it's not like they have some absolute prohibition against doing sequels.