Some of my faves:
-Kirk to Baris in The Trouble With Tribbles: "I have never before questioned the intelligence of any representative of the Federation . . . until now!"
-The Proconsul to Merrick, when he's relating to Kirk as a man, in Bread & Circuses: "Would you leave us, Merrick? The thoughts of one man to another cannot possibly interest you!"
-Picard to Ardra in The Devil's Due, in response to her trying to seduce him:
ARDRA: Don't you find me alluring, Picard?
PICARD: On the contrary. I find you obvious and vulgar.
-Sisko to Weyoun, don't recall the ep: "I don't like the Dominion, I don't like what it stands for, and I don't like you. So let's skip the pleasantries and stick to business."
There's a great exchange between Sisko and Dukat (again, don't recall the ep title) where they trade barbs about titles. Sisko is surprised that Dukat hasn't promoted himself back to the higher rank of Legate, and Dukat says he prefers the hands-on title of Gul, which isn't as pretentious as Emissary. Sisko replies there's a better title for Dukat: "How about Dominion puppet?"
Red Ranger