Though one thing lately that has really p*ssed me off in regards Gene Roddenberry is the fact that he blamed working on Star Trek and the long hours for the failure of his marriage at the time.
He was already making TV shows long before Star Trek. GR wrote for "Have Gun, Will Travel", among numerous other series, and produced shows like "The Lieutenant".
The news that Majel Barrett was his actually his mistress didn't really break during TOS, but after the series ended and they began appearing at conventions together, got married, and had "Little Rod". But when GR was speaking at his university lectures and ST conventions, and asked about the early days of ST, he's hardly going to say, "Oh yes, you see I had this mistress at the time, and I cast her as the female lead of 'The Cage' - and used the ol' traditional Hollywood casting couch to select all our female guest stars."
I doubt GR actually blamed ST itself for the state of his first marriage, but blaming the rigors of Hollywood TV production in general, sure! And that would be perfectly correct.