That's what I did. I went to the Grand Canyon by way of Vegas because it was so cheap. But I did stay overnight just to look around and have the Vegas experience. No luck with seeing Dan Tanna, though.I've seen the inside of the airport and the rental car counter, that's about it. Then we high tailed it out of town. Had no interest in Vegas, but it was a great place to fly into to see the Desert Southwest.
Zion and Death Valley Netional Parks are 3 hours away from LV, albeit in opposite directions. I saw Death Valley.
I also made a point to see the Hoover Dam, which is 90 miles away. Being a civil engineer, it was mandatory.