Thinking big: less chance of failure, from either the stresses on the ship or the crew, physical and mental.
I remember some SF film, might have been '2010' (hmm, next year) where there were 2 spinning rings, in either direction, which is much easier than having the ship spinning.
You need room for the crew to stretch out and get away from each other. Think about a long journey in a car when your a kid. It soon gets boring and, in some cases, sticky. Now think about a 2 to 3 year mission to Mars. You'll really want a place to get away to. Obviously you couldn't live in an Apollo capsule or even a shuttle size ship for anything more than a week, no matter how good the facilities. A couple of guys have lived in ISS for a year, but I don't think they'd recommend it. Ask yourself, you're going somewhere and it's going to take a year just to get there. The view out your window, once you're away from Earth, will be spectacularly dull (unless you do a hell of a lot of astronomy). An arboretum give you fresh air, rather than that recycled stuff, plus a bit of green to ease the eye - these things are more important than you might think.