For my audio drama I was blessed to get access to a small recording studio and a group of 20+ actors.
The first time I recorded the audio drama it was via a call out on the internet and was a mess. As
Mike mentioned, varying audio quality sucks - when I did a bit of a reboot on the project and suddenly had everyone in the same room no only did the audio quality match (even if it wasn't great - it was the same) but the drama and interaction between the actors was so much higher.
That's my biggest advice to you... if it's AT ALL doable to do it in person, with real people that you can sit and direct... by all means, DO IT.
As far as listening with the same anticipation - it depends on the quality of the script and the production level. IE - if the drama is there in a compelling script and the actors bring that drama to the forefront, you shouldn't have trouble getting an audience.
Personally, on scripts a minute, I went through many revisions with mine, trying to convey all the appropriate details without having to resort to the "freeze frame" in time where a narrator talks to the listener - to me, it's much more effective without those moments.
Feel free to ask me as well if you've got questions; I could give you a link to my project... but I'm not done yet because I'm a lazy ass. For me the problem has been motivation

Can't get going again to continue post-production...