I've long had this idea: TOS era, before Kirk's first five year mission. Four life-long buddies, all in Starfleet. They visit once a year when their postings allow. They attend a Starfleet function together and are given an order they know is wrong (haven't worked that out). They refuse and are drummed out of the service. One is your typical command type guy, the other is an ace pilot, the other a great engineer, and the last a super-smart Starfleet Intelligence prospect. He's the only one of the four SF offers a second chance to. Anyway, our typical command guy (I mean this in a good way, think a younger Riker before he was an asshat) goes home in disgrace and learns that his deceased uncle left him his old freighter in his will. He goes to the yards and inspects the ship. Turns out she's in great condition, despite being old. The command guy decides to take his uncle's ship (don't have a name) and go out and get away from it all. He convinces two of his other friends, but the smart guy's a tough sell. They eventually all head out with no clear goal in site. They pick up a fat and greasy drunk pilot in a Rigellian bar who saves their necks after they piss off a few Orions. Not long afterwards, they come across a wrecked Starfleet science vessel. Most of the crew is dead, except for five officers, one of whom is a nurse. They bring them aboard, only to have the other four officers die from their injuries. The nurse eventually joins their makeshift crew and together, they have adventures.