Interesting question. I suppose, in a way, my parents' house will always feel like home to me: I spent many, many years there, all with a loving family, so really, how could it not feel like home? I still visit often, and my folks have told me that they hope I'll always think of the place as home.
Of course, even home can get a little wearisome after a while, or at least it did for me. After twenty-five years there... I needed a change, to put it mildly. I yearned for independence, so I moved out.
I've lived in a couple of okay places since then, and I certainly don't regret moving out of my parents' house (and city), but I've yet to find somewhere new that really, truly feels like "home". I think I came close last year, with the place I'm living in now. It felt like a great place to be, in no small part, I think, because of the good roommates I had. The atmosphere was, for the most part, terrific. Now, they've all moved out. I'm living with virtual strangers again. I have no issues with any of them, but it's just not the same. As corny as it may sound, it does often seem like home is not so much a place, but rather the people you share it with.
For me, it's Ottawa. I moved there for university back in 2005, and lived there until late-last year, when I moved down to the Niagara Region for more school. I'm really hoping to get a job there and move back up, as I love the city. It's got a great "big small-town" feel to it, has some awesome neighborhoods, and is just a great city to live in overall. I miss it.
Ah, Ottawa... I've never been. I really should see it one of these days, though. One of my aforementioned roommates/pals is from the Ottawa area, and he just moved back there a couple months ago. Perhaps I'll pay him a visit in the near future.