Not sure it qualifies as a 'scene' but I always liked the first sentence of Half a Life, exterior shot of Enterprise, voice-over:
Counsellor Deanna Troi, personal log, stardate 44805.3. My mother is on board.
<meaningful silence before scene in interior starts>
Counsellor Deanna Troi, personal log, stardate 44805.3. My mother is on board.
<meaningful silence before scene in interior starts>
It's likely Rome survives until at least Phlox' time (as he visits st' Peters Basilica to attend mass), so presumably it's still there in the 24th century, too, so it would be unlikely he never heard of it, even if he wasn't interested in history.