When the MU was last shown on DS9, the Klingon-Cardassian Alliance was still locked in war with the Terran Rebellion, but there's no indication of what really happens after this. The Bajoran wormhole has been discovered, so the Alliance has to come in contact with the Dominion at some point, what will happen then? And then there's that massive supernova that destroys Romulus in 2387 and goes on to threaten the galaxy; I should imagine that would cause a considerable amount of chaos and destruction. All in all, the outlook doesn't look too promising for the MU.