Let me whip out my Super Secret Paramount Mega Guide to what will be happening with the franchise in the next two decades:
2258: After saving Earth from its near-annihilation due to the very beings who brought about their reality, Kirk, Spock and the rest of the Enterprise crew are given the once-in-each-lifetime opportunity to boldly go where no one has gone before. Along the way, they happen upon strange new worlds, and new civilizations. Scotty gets really excited all the time because the ship is full of drama, and Uhura makes the most difficult decision of her career when she realizes Kirk is hot. On Earth, Starfleet Headquarters greedily devours all surviving pieces of future technology from the Romulans in an effort to assert human dominance throughout the galaxy.
2260: After two years trekking the final frontier, the crew of the Enterprise is slapped upside the head with the painfully obvious realization that the Klingons don't like them. Not one but two planets explode during the course of the short but significant war, and Sulu slays thirty-seven Klingons with his 1337 skills and Asian charms. A last-ditch rush for Qo'Nos to negotiate peace terms before the entire Federation shatters undermines the efforts of the vast majority of psychopathic Klingon warriors when Kirk agrees to cut his hand open and drink his own blood, or something, to show that Starfleet really cares. Kor thinks he's awesome and they become such good friends, Spock gets jealous and Bones angsts for weeks.
2261: The Enterprise crew gets called back from the fringe when a deadly prototype weapon devastates Florida, because it's always Florida, you know. Starfleet blames the Xindi, but Kirk refuses to believe it because he's never even heard of the Xindi. Spock Prime comes back long enough to confirm that he hasn't, either, and then disappears because Leonard Nimoy wouldn't commit to more than a single scene, which is fine, I'm not bitter at all. To prove his suspicions that it's those damned Romulans again, Kirk takes his ship into Romulan territory, where some warbirds show up and beat the crap out of the Enterprise. They leave it inoperable so Kirk devises an awesome plan to abandon ship when the Romulans come aboard, and Spock says that sounds like something he'd do. The ship explodes, and for some mysterious reason the planet they're orbiting above also explodes. Some crucial stuff happens and the crew screw with the Romulans' collective mojo again, but then the Borg show up because they were behind the attacks on the outposts across the Neutral Zone, which Kirk had never even heard of, but whatever. So the Borg are narrowly defeated because of obscure science and Starfleet celebrates. Kirk reiterates that he's never heard of the Xindi and they all share a laugh.
2265: Featured for the fourth time, Kirk and his crew are driving around the Alpha Quadrant at ludicrous speed aboard their new Enterprise-Again when the Borg come back in full force. A bunch of increasingly-ridiculous crap happens, Uhura has Spock's love child, something called V'Ger shows up and is important, and then the Borg are defeated with the reluctant help of the Klingons. The entire ordeal is a mess of convoluted details and Chekov dies for shock effect. It's really annoying.
2268: The Dominion's furthest scouts return, discovering Spock Prime's existence and thus the very nature of their own. Alarmed and disgusted, the Founders push their plans forward by not 200 but a whopping 300 years. Jem'Hadar arrive through the wormhole en masse, but thanks to all the Borg nonsense, the Federation is prepared. Their ships are, like, super-strong. Like, you wouldn't believe it. So gosh-darn strong. Unfortunately, the Dominion wins anyway because victory is life and stuff. Earth explodes at the end of the movie and Kirk comments that he is now a member of an endangered species. Spock, who has secretly never forgiven Kirk for getting all buddy-buddy with that Klingon dude, tells Kirk that it 'hurts, donut' and punches him in the face.
2369: Kira Nerys falls in battle, having resisted the Dominion scourge upon her world her entire life. Terok Nor explodes, and then Bajor explodes. The wormhole explodes, too, though, so the Dominion forces in the Alpha Quadrant get stranded there. Sucks to be them.
2409: The galaxy explodes, because warp technology is bad for you, m'kay?
