The series makes very little sense. Scientifically, it's not up to 19th Century standards, let alone 20th or 21st; many events of the show are completely ludicrous, but masquerade as "fringe" science. What Fringe offers would be better described as bad pseudoscience.
If you remember middle school physical science or high school biology, it's unwatchable.
It's not a class in school. It's entertainment. Oh, and yes, it is absolutely my favorite Sci-Fi show on the air (only surpassed by The Office, 30 Rock, Chuck, and Psych for non Sci-Fi too!!). It's utterly fantastic. The first few episodes are not as good though.