One thing I think non-trekkies would want to go for at first would be characters they already know from the TV series and/or movies. That's also another reason to leave out any books that take place after the TV series and/or the movies and are mostly new characters.
No Voy-R, no SCE/CoE, No Vanguard, no New Frontier, no Klingon Empire, no DS9-R, no TNG-R, no Ent-R, no Myriad Universes, no Mirror Universe and no AoTF
No Voy-R, no SCE/CoE, No Vanguard, no New Frontier, no Klingon Empire, no DS9-R, no TNG-R, no Ent-R, no Myriad Universes, no Mirror Universe and no AoTF